Proto-Oncogene Proteins c-akt

Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.

Also Known As:

Protein Kinase B; AKT1 Protein Kinase; AKT2 Protein Kinase; AKT3 Protein Kinase; Akt-alpha Protein; Akt-beta Protein; Akt-gamma Protein; Protein Kinase B alpha; Protein Kinase B beta; Protein Kinase B gamma; Protein-Serine-Threonine Kinase (Rac); Proto-Oncogene Protein Akt; Proto-Oncogene Protein RAC; Proto-Oncogene Proteins c-akt1; Proto-Oncogene Proteins c-akt2; Proto-Oncogene Proteins c-akt3; RAC-PK Protein; Rac Protein Kinase; Rac-PK alpha Protein; Rac-PK beta Protein; Related to A and C-Protein; c-akt Proto-Oncogene Protein; Akt alpha Protein; Akt beta Protein; Akt gamma Protein; Akt, Proto-Oncogene Protein; Protein, akt Proto-Oncogene; Protein, c-akt Proto-Oncogene; Proteins c-akt1, Proto-Oncogene; Proteins c-akt2, Proto-Oncogene; Proteins c-akt3, Proto-Oncogene; Proto Oncogene Protein Akt; Proto Oncogene Protein RAC; Proto Oncogene Proteins c akt; Proto Oncogene Proteins c akt1; Proto Oncogene Proteins c akt2; Proto Oncogene Proteins c akt3; Proto-Oncogene Protein, akt; Proto-Oncogene Protein, c-akt; RAC PK Protein; RAC, Proto-Oncogene Protein; Rac PK alpha Protein; Rac PK beta Protein; Related to A and C Protein; akt Proto Oncogene Protein; alpha Protein, Rac-PK; c akt Proto Oncogene Protein; c-akt, Proto-Oncogene Proteins; c-akt1, Proto-Oncogene Proteins; c-akt2, Proto-Oncogene Proteins; c-akt3, Proto-Oncogene Proteins; akt Proto-Oncogene Protein; c-akt Protein

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        Proto-Oncogene Proteins c-akt: 2595
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - Proto-Oncogene Proteins c-akt: 2595
  - Neoplasm Proteins: 2
    - Oncogene Proteins: 7793
      - Proto-Oncogene Proteins: 7
        Proto-Oncogene Proteins c-akt: 2595

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Disease

Drug/Important Bio-Agent (IBA)